Focus on key neurologic functions (executive function, cognitive control) or neuropsychiatric disease states. •Consider known brain pathways in this discussion.

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1.Put together a 2 page background on the neurotoxic effects of Mn and PM2.5 in children. I don’t believe that there is much published on the latter.

I would recommend taking the following steps:(from supervisor)
•Search Pubmed on the topic focusing on human studies in children and Mn/PM2.5.
•Also search under the above nvestigators and Maryse Bouchard and Donna Mergler.
•Focus on key neurologic functions (executive function, cognitive control) or neuropsychiatric disease states.
•Consider known brain pathways in this discussion. For Mn, neurologic functions affected should relate to basal ganglia circuits. For PM2.5, it is less clear but possibly more diffuse cortical functions.

2 Write a paragraph on the significance of the study: I have also attached an example Significance section from the study done
Here is a summary of what would be helpful to develop a study to address the issues facing the Meyerton community.

I have attached the abstracts from Roberto Lucchini’s Italian R01, Erin Haynes completed child Mn R01 in Ohio, and Robert (Bob) Wright’s completed lead study in Mexico City. Bob is also studying Mn in Mexico City and I thought it was relevant that he is studying stress-Pb interactions.
in Meyerton R01.
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