Explain the ionic basis of the “anode-break response” of a normal axon membrane.

Write a brief essay for each question:
For questions 1 – 4 assume an isopotential axonal membrane patch.

1. explain what happens to the membrane potential when 100% of Na channels are suddenly opened (assume no voltage dependent conductances)
2. explain the ionic basis of an IPSP
3.explain what happens to the membrane potential when 50% of Na channels are suddenly opened (assume that Na and K conductance channels ARE voltage dependent).
4. Explain the ionic basis of the “anode-break response” of a normal axon membrane.
5. Explain the pathophysiology of Parkinson’s Disease.

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