Discuss with example how bioinformatics can be used for manipulation of nucleic acid sequence and in molecular epidemiological typing

i need answer of this example question that is come in previous year final exam of molecular
Q/ molecular epidemiological typing of viruses can be achieved using a variety of techniques. Describe different techniques that may be used, their relative merits and give examples of how they may be applied in the clinical virology laboratory?
a) what is techniques may be used?
b) how do they compare to each other?
c) consider what epidemiology means: source, number of cases, relationship , etc.

I need part d 250 words in separate part
D) discuss with example how bioinformatics can be used for manipulation of nucleic acid sequence and in molecular epidemiological typing ( example should be with tools used for analysis and an example of how they can be used.)

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